Hypersensitivity to barbiturates or any ingredient on the formulation; ; history of manifest or latent porphyria
butabarbital will lower the extent or influence of cyclosporine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
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butabarbital will lower the extent or impact of siponimod by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration of siponimod by using a drug that triggers reasonable CYP2C9 furthermore a moderate or sturdy CYP3A4 inducer just isn't proposed.
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Felbamate: May improve the serum focus of Barbiturates. Barbiturates may well lessen the serum concentration of Felbamate. Administration: Watch for elevated barbiturate concentrations/toxicity if felbamate is initiated/dose increased, or lowered concentrations/effects if felbamate is discontinued/dose reduced. Make reference to phenobarbital dosing tips for individuals getting that agent. Keep track of therapy
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Exceptions to this monograph are reviewed in further depth in separate drug conversation monographs. Consider therapy modification
butabarbital will reduce the extent or influence of temsirolimus by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
butabarbital will lower the extent or effect of lonafarnib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib is really a delicate CYP3A4 substrate. Coadministration with powerful or moderate CYP3A4 inducers is contraindicated.
In addition to its desired results, a drugs may well lead to some unwanted outcomes. While not most of these Negative effects may well occur, whenever they do occur They could require professional medical interest.
butabarbital will lessen the level or read more result of carbamazepine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
You might get drowsy or dizzy. Usually do not travel, use equipment, or do anything at all that requirements mental alertness right until you understand how this drugs affects you.
When put together use is required, consider reducing doses of a number of medicines. Usage of sodium oxybate with Alcoholic beverages or sedative hypnotics is contraindicated. Consider therapy modification